LESCOL XL Dosing


			Pharmacokinetics

LESCOL^® XL Dosing¹

Patients should be placed on a standard cholesterol-lowering diet before receiving
LESCOL^® XL, and should continue on this diet during treatment with LESCOL^® XL, as with all statins.

The recommended daily dose for 25% or greater reduction in LDL-C is a single 80 mg dose of LESCOL^® XL.

LESCOL^® XL

Can be taken without regard to meals, since there are no apparent differences in the lipid-lowering effects of fluvastatin sodium administered with the evening meal or 4 hours after the evening meal
Can be taken at any time of day for maximum convenience
Maximum reductions in LDL-C have been seen within 4 weeks of treatment
Periodic lipid determinations should be performed
The therapeutic effect of LESCOL^® XL is maintained with prolonged administration
Low potential for clinically significant CYP450 3A4 drug-drug interactions²
Is predominantly metabolized by the CYP450 2C9 pathway¹
Approximately 60% of prescription drugs are metabolized by the cytochrome P450 3A4 pathway³
Although changes in pharmacokinetics have been observed when immediate release fluvastatin has been administered with cytochrome P450 3A4 inhibitors/substrates, the clinical significance of these effects has not been shown.

LESCOL^® XL is supplied as 80 mg extended-release tablets for oral administration in bottles of 30 or 100 tablets.

References:
1. LESCOL ^® XL full Prescribing Information.
2. Farnier M, Bortolini M, Salko T, et al. Frequency of creatine kinase elevation during treatment with fluvastatin in combination with fibrates (bezafibrate, fenofibrate, or gemfibrozil). Am J Cardiol. 2003; 91:238-240.
3. Zhou S, Yung Chan S, et al. Mechanism-based inhibition of cytochrome P450 3A4 bytherapeutic drugs. Clin Pharmacokinet. 2005;44:279-304.

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